The e-book highlights the main theoretical and applied aspects related to the modeling and implementation of digital control systems (DCSs) from the perspective of their application in the Cyber-Physical Systems. The main attention is paid to the construction of MCU-based DCSs: from DC motor control system and network to intelligent control systems of UAV swarm with using of embedded models, artificial neural networks and fuzzy control. A separate section presents DCSs based on programmable logic devices, namely FPGA. Hardware and software components of considered DCSs’ examples is accompanied by a comparative analysis of modern technologies and tools their modeling and implementation. This e-book can be served a textbook for graduate and postgraduate students as well as teachers in computer and electrical engineering to a better understanding of the current trends and prospects for digitalization in the field of control, responding to the challenges of Industry 5.0. The e-book was developed within the EU-supported ERASMUS+ project.