Development of Benzoxaphosphepine Derivatives as Selective Carbonic Anhydrase Inhibitors

Summary of Doctoral Thesis

Anastasija Balašova, Riga Technical University, Latvia
ORCID iDhttps://orcid.org/0000-0002-1185-1922

The Doctoral Thesis focuses on the development of novel phosphorus‑containing carbonic anhydrase inhibitors, which show potential as anticancer drug candidates. In this study, a synthetic route to previously unreported benzoxaphosphepine derivatives was established using ring-closing metathesis. As a result, a series of selective carbonic anhydrase inhibitors possessing nanomolar activity in enzymatic assays was obtained. Information on the structure–activity relationships of the synthesised compounds, in vitrocytotoxicity data, and aqueous solubility is presented. The Thesis has been prepared as a collection of thematically unified scientific publications.

Additional information

Publication type

DOI

https://doi.org/10.7250/9789934372308

Defence date

11.12.2025.

Format

ISBN (pdf)

Pages

51

Publication date

Published online

Publication language

,

Publisher

RTU Press

Country of Publication

Latvia