Structural and Functional Studies of Proteins Involved in the Regulation of Fatty Acid Metabolism
Summary of the Doctoral Thesis
Diana Zelencova-Gopejenko, Riga Technical University, Latvia
https://orcid.org/0000-0002-6931-2294
Description
The Doctoral Thesis is devoted to structure-activity relationship studies of γ-butyrobetaine dioxygenase, ε-trimethyl-l-lysine dioxygenase (TMLD), and heart-type fatty acid binding protein (FABP3) ligands. Protein-ligand binding was determined and characterized by means of isothermal titration calorimetry (ITC), nuclear magnetic resonance, and molecular modelling. Two new ITC approaches were established and implemented for the determination of ligand binding thermodynamics to TMLD and FABP3. A new class of FABP3 substrates with a different binding mechanism in comparison to fatty acids was found.
About the author
Additional information
| Publication type | |
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| DOI | |
| Defence date | 21.06.2023. |
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| Pages | 52 |
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| Publisher | RTU Press |
| Country of Publication | Latvia |
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