1,4-Dihidropiridīna atvasinājumu fizikāli-ķīmiskā un in silico izpēte. Promocijas darbs. cover

1,4-Dihidropiridīna atvasinājumu fizikāli-ķīmiskā un in silico izpēte

Doctoral Thesis

Ruslans Muhamadejevs, Riga Technical University, Latvia
ORCID iD https://orcid.org/0000-0001-6827-7290

The Doctoral Thesis is devoted to the study of 1,4-dihydropyridine (1,4-DHP) derivatives with various physicochemical methods and quantum chemical calculations. For the bromination reaction of the 1,4-DHP derivative with N-bromosuccinimide, previously undescribed intermediates were identified by NMR. An unusual temperature dependence of the AB system of the diastereotopic methylene protons of 1,4-DHP derivatives was observed by NMR. NMR and IR experiments revealed an anomalous |N-H| bond shortening upon hydrogen bond formation. The binding of 5′-mononucleotide monophosphates to cationic lipid-like 1,4-DHP derivatives has been characterized by isothermal titration calorimetry and NMR.

Additional information

Publication type

Defence date

19.06.2023.

Format

Pages

145

Publication date

Published online

Publication language

Publisher

RTU Press

Country of Publication

Latvia