Semisynthesis of Exotic Terpenoids from (–)-β-caryophyllene

The Thesis describes the development of synthetic methods towards exotic marine and terrestrial natural products from β-caryophyllene. Due to its wide availability in enantiopure form, β-caryophyllene and its oxide were used in the Thesis to obtain biologically active and structurally complex terpenoids. The established synthetic routes enabled the preparation of final compounds up to gram scale as well as allowed for the structure confirmation/revision and the proposal of biosynthetic pathways of target terpenoids. The structures of the final products were unambiguously determined by single-crystal X-ray diffractometry.