Summary of the Doctoral Thesis "Synthesis of a New Type of Carbonic Anhydrases Inhibitors" cover

Synthesis of a New Type of Carbonic Anhydrases Inhibitors

Summary of the Doctoral Thesis

Aleksandrs Pustenko, Riga Technical University, Latvia

The Doctoral Thesis has been prepared as a thematically united collection of scientific publications. It consists of a summary and five scientific publications. Publications have been written in English, their total volume is 39 pages. A new, selective class of CA IX and CA XII inhibitors – 3H-1,2-benzoxathiepine 2,2-dioxides, has been found. A series of 3H-1,2-benzoxathiepine 2,2-dioxide triazolyl, acylamino and aryl derivatives was synthesized. We discovered that furagin, a clinically used antibacterial agent, is a selective inhibitor of CA IX and CA XII. Developing this concept, we synthesized a series of imidazolidine-2,4-dione derivatives. Inhibitory activity on relevant human CA isoforms (I, II, IX, and XII) was determined for all products synthesized within the scope of the Doctoral Thesis.

Additional information

DOI

https://doi.org/10.7250/9789934225024

Hyperlink

https://ortus.rtu.lv/science/en/publications/31148

Publication type

Defence date

30.09.2020.

ISBN (print)

978-9934-22-501-7

ISBN (pdf)

978-9934-22-502-4

Format

Pages

57

Published online

Publisher

RTU Press

Country of Publication

Latvia

Publication language

,

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