Bakteriālo divkomponentu sistēmu inhibitoru sintēze. vāks

Synthesis of Bacterial Two-component System Inhibitors

Summary of the Doctoral Thesis

Vitalii Solomin, Riga Technical University, Latvia

The thesis is focused on the development of new histidine kinase two-component systems inhibitors in order to defeat antibiotic resistant bacteria. For the synthesis of perspective inhibitors, synthetic approach of assembling of 2-aminoquinazoline and indazole heterocyclic motifs were elaborated. As a result, a series of new 2-aminoquinazoline-based inhibitors of histidine kinases two-component systems was developed. In addition, perspective phenylazole-based antibacterials active against S. Aureus were studied and described.

Additional information

Publication type

DOI

https://doi.org/10.7250/9789934229435

Defence date

13.07.2023.

Format

ISBN (pdf)

Pages

87

Publication date

Published online

Publication language

,

Publisher

RTU Press

Country of Publication

Latvia