Synthesis of Bacterial Two-component System Inhibitors. cover

Synthesis of Bacterial Two-component System Inhibitors

Doctoral Thesis

Vitalii Solomin, Riga Technical University, Latvia

The thesis is focused on the development of new histidine kinase two-component systems inhibitors in order to defeat antibiotic resistant bacteria. For the synthesis of perspective inhibitors, synthetic approach of assembling of 2-aminoquinazoline and indazole heterocyclic motifs were elaborated. As a result, a series of new 2-aminoquinazoline-based inhibitors of histidine kinases two-component systems was developed. In addition, perspective phenylazole-based antibacterials active against S. Aureus were studied and described.

Additional information

Publication type

Defence date

13.07.2023.

Format

Pages

182

Publication date

Published online

Publication language

Publisher

RTU Press

Country of Publication

Latvia