The Development of New Methods for the Synthesis of PLP- Dependent Enzyme Inhibitors and Exploring Covalent Inhibition Potential of Bacterial Enzyme O-acetylserine Sulfhydrylase. cover

The Development of New Methods for the Synthesis of PLP- Dependent Enzyme Inhibitors and Exploring Covalent Inhibition Potential of Bacterial Enzyme O-acetylserine Sulfhydrylase

Summary of the Doctoral Thesis

Konstantinos Grammatoglou, Riga Technical University, Latvia
ORCID iD https://orcid.org/0000-0002-0910-1444

The Thesis is a collection of scientific publications focused on the synthesis of triF-Ala analogues as potential inhibitors of PLP-dependent enzyme OASS and the development of methods for the synthesis of PLP-dependent enzyme inhibitors. Direct C–H functionalization of tetrazoles was achieved using the turbo Grignard reagent (iPrMgClꞏLiCl). In addition, an electrochemically removable protecting group was used on tetrazoles, and the use of enantiomeric t-butanesulfinyl imines as electrophiles can deliver the corresponding addition products in diastereoselective manner.

Additional information

Publication type

DOI

https://doi.org/10.7250/9789934229237

Defence date

14.06.2023.

Format

ISBN (pdf)

Pages

72

Publication date

Published online

Publication language

,

Publisher

RTU Press

Country of Publication

Latvia

Funding source