Biomateriāli uz oktakalcija fosfāta bāzes: iegūšana, modifikācija un pielietojums

Within the Doctoral Thesis, the synthesis methodology and upscaling of octacalcium phosphate (OCP) production from low-temperature α-tricalcium phosphate (α-TCP) have been optimized, and a comprehensive analysis profile of the obtained OCP has been established. To ultimately utilize the data from the physicochemical analysis, an in silico model capable of identifying the production stage of OCP has been designed. The developed OCP has been applied in two approaches: as a doxorubicin hydrochloride (DOX) drug delivery system for the treatment of osteosarcoma and as a protective coating against corrosion for titanium implants. The doxorubicin-octacalcium phosphate (DOX-OCP) drug delivery system was characterized, and the in vitro drug release and biological effects on MG63 (cancer cells) and MC3T3-E1 (normal cells) were studied. Sodium alginate/octacalcium phosphate (Alg/OCP) composite coatings were developed, and their electrochemical behaviour on titanium alloys in inflammatory conditions was assessed.